Two CRC cell lines were selected: i) HT-29 cells, which express high level of E-cadherin but low level of Ucn2 and no vimentin; ii) SW620 cells, poorly differentiated mesenchymal cells which express high levels of Ucn2 and vimentin compared to a weak level of E-cadherin (Figure 2A). The gene discussed is CDH1; the disease is colorectal carcinoma.