To elucidate the relationship between the two polymorphisms and its effect on CAD risk, we herein conducted a meta-analysis to (1) assess the effect of the SELE gene polymorphisms (A561C and G98T) on the risk of CAD; (2) evaluate the potential heterogeneity among studies; and (3) explore the potential publication bias. The gene discussed is SELE; the disease is coronary artery disorder.