Many STAT1-57 genes were also annotated with the GO BP terms “response to type I interferon” or “response to interferon-gamma” (e.g., IFI27, IFI35, IFI6, IRF9, OAS2 and OAS3), and consistent with this, STAT1-57 genes were disproportionately induced in cultured KCs following treatment with either IFN-α or IFN-γ (Figures 4, 5B and 5C; P≤4.9×10−19 by GSEA). This evidence concerns the gene IFI27 and dry eye syndrome.