We identified one PP-decreased DEM with genes biased towards hyper-methylation in psoriasis lesions (i.e., PTEN-28; P = 0.01; FDR = 0.16; GSEA), along with two PP-increased DEMs with genes biased towards hypo-methylation (i.e., STAT3-30 and WNT5A-48; P≤0.023; FDR ≤0.23; GSEA) (Figure S12). The gene discussed is WNT5A; the disease is psoriasis.