Finally, a role for RIG-I in T-cell activation is supported by one study of RIG-I(−/−) mice, which showed that RIG-I(−/−) mice develop a colitis-like phenotype with decreased numbers of CD44lowCD62Lhigh naïve T-cells, but increased CD44highCD62Llow effector T cells and CD44highCD62Lhigh memory T cells [58]. This evidence concerns the gene RIGI and colitis.