There was also a striking trend in which STAT1-57 genes were elevated in KCs following siRNA knockdown of TP63 (P = 5.9×10−18; GSEA; Figure 5D), the transcription factor ZNF750 (P = 1.0×10−6; GSEA; Figure 5E) and the transcription factor KLF4 (P = 1.3×10−4; GSEA). This evidence concerns the gene KLF4 and dry eye syndrome.