PP-increased DEGs included a disproportionately high number of genes associated with susceptibility loci for inflammatory bowel disease, celiac disease and Crohn’s disease (Figure S5; P≤4.8×10−5; FDR ≤0.007; Fisher’s Exact Test), and we identified 5 PP-increased DEGs associated with all three conditions (PVT1, REL, IL18RAP, GSDMC, PUS10; Figure S6). The gene discussed is PUS10; the disease is Crohn disease.