The linkage analyses uncovered a 27.1 Mb region on the 5q31 band, which is one of the most gene-rich genomic segments in human, and several known disease loci (genes) have been previously identified on 5q31 in linkage with hereditary HL including DFNA1 (DIAPH1), DFNA15 (POU4F3), DFNA42, and DFNA54 [17]–[19]. The gene discussed is POU4F3; the disease is Hodgkins lymphoma.