While all of the above point towards a benefit of lower TGF-β levels in allergic rhinitis, pollen-specific immunotherapy significantly increases serum TGF-β levels that are correlated with higher IgA synthesis [36], down-regulation of Th2 responses [37] and prevention of eosinophilia and inflammation [38]. The gene discussed is TGFB1; the disease is Increased total eosinophil count.