More specifically, knockdown of plakoglobin in MCF-7 cells resulted in the increased mRNA and protein levels of the tumor/metastasis promoters c-Abl, Snail, ErbB2 and MMP3 and the decreased levels of tumor/metastasis suppressors BRMS1, Kiss1 and Claudin-1. The gene discussed is SNAI1; the disease is neoplasm.