AGER and melanoma: This is particularly prominent in tumor models, where DN-RAGE only blocks RAGE-ligand signaling but also tumorigenesis and metastasis in multiple cancers including breast, colorectal, prostate, pancreatic, brain, lung, oral squamous cell, ovarian, as well as lymphoma and melanomas [1], [13], [18], [20], [4], [7]–[12].