Interestingly, our case-control study demonstrated that the AA homozygote in TERT rs2736098 exhibited a significantly increased risk of developing NSCLC (OR = 1.48, 95% CI = 1.05–2.09, P = 0.025), especially adenocarcinoma (OR = 1.67, 95% CI = 1.12–2.50, P = 0.013), compared with those who carry the GG genotype. The gene discussed is TERT; the disease is adenocarcinoma.