PFKM and breast carcinoma: The PFK-1 activities in the human breast cancer and paracancer tissues of each clinical stage were 15.7±1.92 vs. 5.71±0.366 U/gprot (P=0.024), 18.6±1.48 vs. 5.39±0.459 U/gprot (P=0.018) and 20.2±1.94 vs. 5.48±0.612 U/gprot (P=0.010), respectively (Fig. 2B).