ERBB2 and gastric neoplasm: Furthermore, common gastric tumors that are classified as intestinal types are more likely to be HER-2 positive (16–34%) compared with diffuse (2–7%) or mixed (5–20%) types (11–12,14,15), although certain aggressive variants, including hepatoid gastric carcinomas, have been shown to exhibit the highest HER-2 immunoreactivity (16).