Osteopontin (OPN), a secreted, non-collagenous, extracellular matrix protein that belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family, plays a significant role in determining the oncogenic potential of various cancers and is recognized as a key marker in the processes of tumorigenicity and metastasis (4). This evidence concerns the gene SPP1 and cancer.