A clinical data analysis has demonstrated that NDRG1 overexpression is correlated with a large tumor size, portal vein invasion, TNM stage, an AFP level of ≥400 U/l, intrahepatic metastasis, recurrence and poor patient survival, and that HCC patients who have positive NDRG1 expression generally have a worse prognosis than those who have no expression (11–13,18). This evidence concerns the gene NDRG1 and hepatocellular carcinoma.