However, some have reported prognostic significance of HOXA11 hypermethylation in other types of cancers: HOXA11 hypermethylation is more frequent in recurrent endometrial adenocarcinoma than in non-recurrent endometrial adenocarcinoma and is associated with poor prognosis in early stage endometrial adenocarcinoma. This evidence concerns the gene HOXA11 and endometrium adenocarcinoma.