Interestingly, recent genome-wide sequencing projects identified low frequencies of samhd1 somatic mutations in several types of human cancer, including leukemia, lung adenocarcinoma, myeloma, medulloblastoma, glioblastoma, pancreatic, and breast and colorectal cancers (discussed in[12,15]). The gene discussed is SAMHD1; the disease is medulloblastoma.