Sengupta et al. found that β-catenin, CyclinD1, HoxA10 and p21 play important role in the signaling network for the apparently diverse but mutually interconnected self-renewal-associated genetic programs of CML cells and this finding was consistent with our results [34]. The gene discussed is HOXA10; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.