Protocols based on daily to weekly oral or subcutaneous injections of macrocyclic lactones including ivermectin, doramectin, and moxidectin have been published but represent off-label use with potential for toxicity, especially in dogs mutated for MDR-1 (P-glycoprotein deficiency), especially including colley breeds [9, 11]. Here, ABCB1 is linked to hyperinsulinemic hypoglycemia, familial, 4.