Although it has been reported that several dystroglycanopathy models with mutations in POMGnT1, LARGE, or fukutin could be recovered by LARGE overexpression, laminin-binding glycans were not rescued by LARGE overexpression in AGO-deficient MEFs (Fig. 2e). This evidence concerns the gene LAMB2 and neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan.