HSF1 and amyotrophic lateral sclerosis: Activation of HSF1 using the HSP90 inhibitor 17-N-allylamino-17-demethoxygeldanamycin (17-AAG) led to an extension in lifespan of a drosophila model of ALS, owing to the upregulation of the drosophila ortholog of αB-crystallin [32].