Since we observed increases in surface hydrophobicity of mutant SOD1 and 16 other non-SOD1 proteins in the spinal cord of H46R/H48Q mice, we set out to determine whether over-expression of HSF1 would be protective against SOD1 mutant-mediated ALS and alteration in proteome surface hydrophobicity. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.