With regards to ALS, 14-3-3 proteins have been shown to modulate NFL mRNA stability [63] and assist in targeting misfolded proteins to aggresomes by linking Bcl-associated athanogene 3 (BAG3) to histone deacetylase 6 (HDAC6) [64,65]. This evidence concerns the gene HDAC6 and amyotrophic lateral sclerosis.