More recently, Jin et al. surprisingly found that p53 directly induced the transcription of miR-149*, which in turn can target the glycogen synthase kinase-3α mRNA, resulting in elevated expression of Mcl-1 and resistance to apoptosis in melanoma cells, thus providing a rational explanation for the poor ability of p53 to suppress melanoma progression [21]. The gene discussed is TP53; the disease is melanoma.