OPHN1 and Parkinson disease: In conclusion, our results suggest that in response to dopamine deprived in the striatum of PD patients, expressions of several genes are changed (OPHN1, Pax6, connexin 43, CaMKII, PRKCA, CDC42 and BCL2) and these genes may play important roles in promoting intrinsic striatal TH interneurons growth and inhibit its apoptosis.