There was a significant correlation between the Gln27 ADRB2 polymorphism and FEV(1) percent predicted value in the Chinese population 39, between Arg16 homozygotes of ADRB2 and an increased risk of symptoms of wheeze in Caucasian participants 40, or between the homozygous variant of EPHX exon 3, the GSTM1-null genotype and independent risk factors for developing severe COPD in the Taiwanese population 29. The gene discussed is ADRB2; the disease is chronic obstructive pulmonary disease.