One retrospective cohort study that included 97 patients in various stages of uterine sarcoma who received different treatment modalities, including surgery, chemotherapy and radiation therapy, indicated that patients with ER-positive uterine sarcoma have a median overall survival of 36 months, while ER negative demonstrated a median overall survival of 16 months (Ioffe et al. 2009). The gene discussed is ESR1; the disease is uterine corpus sarcoma.