BACH1 and hepatocellular carcinoma: Previous study indicated that CoPP-induced upregulation of HO-1 gene expression was mediated by the transcription factors Bach1 and Nrf2 in human hepatoma cells and that the underlying mechanism was attributed to the posttranscriptional destabilization of the Bach1 protein and stabilization of the Nrf2 protein in response to CoPP [13].