For instance, in an analysis of 420 lung cancers, a group of investigators from Germany defined a tumor as highly amplified if the FGFR1/centromere ratio was ≥ 2.0, the average number of FGFR1 signals per tumor cell nucleus was ≥6, or if large clusters ( ≥ 15 FGFR1 signals) were found in ≥ 10% of the counted nuclei. Here, FGFR1 is linked to neoplasm.