Sawaya et al also investigated whether early alterations of myocardial strain and blood biomarkers [Ultrasensitive troponin I, brain natriuretic peptide, and the interleukin family member (ST2)] predict incident cardiotoxicity in eighty-one women with newly diagnosed HER2-positive breast cancer treated with anthracyclines followed by taxanes and trastuzumab [55]. The gene discussed is NPPB; the disease is breast cancer.