The level of plasma NT-proBNP in PAH was 1,582.43±1,387.30 pg/ml with a range of 83.10–4,453.00 pg/ml and the Septal angle had a strong correlation with the level of NT-proBNP (r=0.616, P=0.003). The gene discussed is NPPB; the disease is pulmonary arterial hypertension.