Although, it remains to be determined whether a generalized expression of FVIII within all hematopoietic cell lineages is sufficient for ecotopic expression of FVIII to correct haemophilia A in humans40, or if the strategy presented within this report targeting expression specifically to platelet α-granules has an added advantage of delivering FVIII directly at the site of the vascular injury. This evidence concerns the gene F8 and hemophilia A.