The gene network U contained CD200 antigen (Cd200), dentin matrix protein 1 (Dmp1), fibrillin 1 (Fbn1), insulin-like growth factor 2 (Igf2), lumican (Lum), matrix metallopeptidase 13 (Mmp13), osteomodulin (Omd) and thrombospondin 1 (Thbs1) and was associated with biological functions, such as cardiovascular disease, skeletal and muscular system development and function and organ morphology. This evidence concerns the gene IGF2 and cardiovascular disorder.