To understand information derived from GSEA, we analyzed in details pathways markedly modulated in KEGG database, focusing on the two top enriched collections in R6/2, namely “complement and coagulation cascade” and “PPAR signaling”, together with the two top enriched collections in WT mice, that are “cardiac muscle contraction” and “dilated cardiomyopathy”, emphasizing existing relationships with HD pathology. Here, PPARA is linked to Huntington disease.