However, the most commonly used medulloblastoma-derived cell lines, which we also used here, are not depending on constitutive activation of sonic hedgehog signaling and KDM1A knockdown did not result in any significant change of expression in genes belonging to the sonic hedgehog signaling pathway (Additional file 1: Table S2) [44,45]. The gene discussed is KDM1A; the disease is medulloblastoma.