However, neither the constitutive loss of hepcidin through gene mutations in either human [83] or mouse models of haemochromatosis [84,85] or the targeted loss of ferroportin in the brain [45] appear to cause cerebral or cerebellar dysfunction and a role for hepcidin and ferroportin in the brain is currently undefined. The gene discussed is HAMP; the disease is hereditary hemochromatosis.