SLC40A1 and Alzheimer disease: The primary pathology of AD, that of protein misfolding [5,10], is accompanied by other pathological processes, notably vascular damage with associated ischaemic changes [73,74] and inflammation [75,76] and we believe that the reduction in ferroportin expression found in the present study is likely to be a secondary phenomenon caused by these factors that clearly contribute to AD pathogenesis [77,78].