Specifically, two individuals blinded to disease status rated 29 frontal cortex samples for patterns of TMEM106B staining, as described in Figure 3a (normal controls n = 7; AD n = 5; FTLD-tau n = 6, GRN (+) FTLD-TDP n = 6, GRN (−) FTLD-TDP n = 5). The gene discussed is TMEM106B; the disease is Alzheimer disease.