In addition, the genesets Lee_Targets_ofPTCH1_and_SUFU “_up” and “_dn”,indicative of SHH dependent murine tumorigenesis [45], show consistent differential enrichment; upregulated targets areenriched in mouse network tumours and human tumours with a low Metagene score(Additional file 10: Figure S3E), and downregulatedtargets are enriched in mouse tumours with no mutagenesis and human tumours witha high Metagene score (Additional file 10: FigureS3F). Here, SHH is linked to neoplasm.