Furthermore, activity of this network varied significantlybetween the human subgroups, was associated with metastatic disease, andpredicted poor survival specifically within the SHH subgroup of tumours.Igf2, previously implicated in medulloblastoma, was the mostdifferentially expressed gene in murine tumours with network perturbation,and network activity in both mouse and human tumours was characterised byenrichment for multiple gene-sets indicating increased cell proliferation,IGF signalling, MYC target upregulation, and decreased neuronaldifferentiation. This evidence concerns the gene IGF1 and medulloblastoma.