Consistent with increased Igf2 expression in MBs from mice with networkhits, enrichment of IGF-related genesets is also observed in human and mousetumours; e.g. enrichment of Pacher_Targets_of_IGF1_and_IGF2_upin mouse tumours with network hits (Additional file 10: Figure S3C), and of Boudoukha_Bound_by_IGF2BP2 inhuman tumours with a low Metagene score (Additional file 10: Figure S3D). The gene discussed is IGF1; the disease is neoplasm.