Thiscluster of CIS nodes is highly significant (p=0.006 using 1000 randomlyre-sampled networks) and consists of 6 genes with transcription factor/cofactoractivity (CREBBP, MYT1L, NFIA, NFIB, TEAD1and TGIF2) and one neuronal growth factor (FGF13). This evidence concerns the gene CREBBP and in situ carcinoma.