Compared to the former study, data reported by D'Aloia et al. had larger total patient population across a wide range of HF severity in terms of NYHA functional class (Fc) (Duman et al.: 49, Kouris et al.: 77 versus D'Aloia et al.: 286) leading to larger amount of Fc IV population (Duman et al.: 16, Kouris et al.: 16 versus D'Aloia et al.: 83) in D'Aloia's series, and potentially higher number of subjects (28/49 versus 152/286) having CA-125 above normal range (35 U/ml). This evidence concerns the gene MUC16 and hydrops fetalis.