MUC16 and hydrops fetalis: More or less, accumulating evidence had indicated the mesothelium (pericardial, pleura or peritoneum) as a potential primary source of CA-125 in HF or other non-malignant clinical scenarios [40,41], while data regarding the severity or extent of underlying stimuli, inducing media or modalities, and whether such elevation in HF was also secondarily influenced by effusions per se or other associated cytokines still remained a debate [41].