In general, serum CA-125 level seemed to be 7-fold higher (HF: 105.2 ± 139, range 4.6 to 1169.5 U/ml vs Control: 14.9 ± 22 U/ml, respectively) in subjects with acute HF, 2.5 times in chronic HF (HF: 68 ± 83, range 3 to 537 U/ml) [23] and nearly 1.5 times higher in female HFpEF (HFpEF: 17.6 ± 10.2, range 4.94 to 104.3 U/ml) [18], the value actually had wide range across a heterogeneous spectrum in specific subgroups of HF patients [12,26,29,32,39]. This evidence concerns the gene MUC16 and hydrops fetalis.