MassARRAY assay of 25 candidate genes in seven MCL cell lines and normal B cells showed 20 genes hypermethylated in more than one MCL cell line, encompassing cell differentiation (SOX9), cell adhesion (CDH1), cell cycle (GOS2) and apoptosis (LGALS3), p53 pathway (CDC14B) and PI3K pathway (THEM4), transcription factors (AHR, HOXA9, NR2F2, FOXC1, TWIST1) and others with unknown functions (ROBO1, NPTX2, CYB1B1, GPX3, MAL, PAX6, PTPRG1, TFPI2). This evidence concerns the gene TWIST1 and mantle cell lymphoma.