Also, the true PSP association could be from nearby genes (e.g. FOXI3 or RPIA) though this is less likely since the signal from SNPs in highlighting these genes are not as significant as SNPs within EIF2AK3. The work presented here clearly demonstrates that in PSP, PERK is activated in a region-specific pattern that matches regions where neurodegeneration occurs. The gene discussed is RPIA; the disease is supranuclear palsy, progressive, 1.