Pathologically, most cases of FTLD bearing the expansion[6-12], like many non-mutational cases of FTLD[2], show inclusion bodies within neurones (NCI) and glial cells of the cerebral cortex and hippocampus that contain the nuclear transcription factor, TDP-43, and are said bear a TDP-43 histological subtype termed FTLD-TDP type B (according to Mackenzie classification[13]), compatible with a clinical diagnosis of FTD and MND. The gene discussed is TARDBP; the disease is mild neurocognitive disorder.