Nonetheless, irrespective of TDP-43 histological type, all patients with FTLD (and indeed those with MND) reported to bear expansion in C9ORF72 also show a unique pathology within the dentate gyrus granule cells and CA4 pyramidal cells of the hippocampus[9] and granule cells of the cerebellum[9,10] characterised by NCI that are TDP-43 negative, but immunoreactive to p62 protein[6-12]. The gene discussed is TARDBP; the disease is mild neurocognitive disorder.