In addition, CXC chemokines (including gro-α) that are secreted by endothelial cells can induce tumor cell invasion, whereas the blockade of the gro-α receptor CXCR2 can inhibit the invasion of oral squamous cell carcinoma-3 and Kaposi’s sarcoma cells into endothelial cells [40]. The gene discussed is CXCR2; the disease is oral cavity squamous cell carcinoma.