Additionally while so far 519 genes of the whole genome were found to be associated with AD (2.59% of the whole genome), we have found that 176 of the 1165 mTOR regulated genes (15.1%) have altered expression in AD indicating that the mTOR pathway has a significant involvement in AD (Chi-square=402.354, p < 0.0001). This evidence concerns the gene MTOR and Alzheimer disease.