In SLE patients analysis of TLR4 SNP along with clinical (cutaneous lesions, arthritis and lupus nephritis) and biological features of SLE showed no significant correlations between this polymorphism frequencies and clinical manifestations, or with increased disease activity (SLEDAI > 8), or with an elevated titer of anti-nuclear antibodies (ANA), the presence of anti-dsDNA (double stranded DNA) antibodies (Abs) and decreased complement activity (DCA). This evidence concerns the gene TLR4 and lupus nephritis.