These nuclear auto-antigens (SLE) and EMD (RA) are damage associated molecular patterns (DAMPs) that might be recognized by Toll-like receptors (TLRs), mainly TLR4 and its co-receptor CD14 paving the way to secretion of pro-inflammatory cytokines (IL-6 and TNFα). This evidence concerns the gene TLR4 and systemic lupus erythematosus.