This absence of correlation with RA susceptibility and/or severity was equally observed in the majority of studies [13,16-18] all but the one performed on a Dutch population [19] including 282 patients and 314 controls, in which the homozygous genotype TLR4*A/A was significantly associated to RA occurrence; p = 0.025; with an estimated relative risk (RR) of 1.7. The gene discussed is TLR4; the disease is rheumatoid arthritis.