In RA patients, again, there were no significant differences between genotypes frequencies and the age of onset, the disease activity, the presence of bone erosions, the occurrence of subcutaneous nodules, the positivity of serological markers [rheumatoid factor (RF) and/or anti-cyclic citrullinated peptide (ACCPA)] and the association of genetic factors (HLA-DRB1*04 allele or shared epitope). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.