Nonetheless, a subset of PM-COX subjects with clinical presentation suggestive of IBM showed high labeling for autophagic markers LC3 and p62, but not for aggregation marker TDP-43; this finding supports the hypothesis that autophagy impairment occurs early and accumulation of misfolded proteins late in IBM pathogenesis [12,25]. The gene discussed is SQSTM1; the disease is inclusion body myositis.