TARDBP and inclusion body myositis: In our study, LC3, p62, and TDP-43 all effectively distinguished the IBM subject group from the PM subject group; however, LC3 immunohistochemistry showed the best tradeoff between sensitivity and specificity for IBM as a diagnostic test applied to an individual case (100% specificity and 83% sensitivity for IBM using a threshold value of 13.4%FS; Figure 2a).