GPCR targeted radiotherapy, in which an isotope, such as lutetium-177 or yttrium-90, is attached to a receptor ligand, antibody or other molecule in order to target the radioactivity to the desired GPCR, has been successful in the treatment of neuroendocrine tumors and other malignancies [40,41]. This evidence concerns the gene LPAR3 and neuroendocrine neoplasm.