Furthermore, we found PTGER4 to be uniquely over-expressed in the SHH subgroup of medulloblastoma (16-fold, p = 0.02; Additional file 3: Table S2) and this finding replicated what was also seen in the Boston and Heidelberg tumor cohorts (Figure 3e, g) [8,11]. The gene discussed is PTGER4; the disease is medulloblastoma.