ADORA1 was under-expressed in the Non-WNT/SHH group (0.088-fold, p = 0.03), again suggesting that loss of ADORA1 activity may play a role in the pathogenesis of a Non-WNT/SHH medulloblastoma tumors, especially those seen in Cluster “E” (Table 1). The gene discussed is SHH; the disease is medulloblastoma.