When the 35 kDa serum ITIH4 fragment cluster was analysed by densitometry, significant up-regulated expression was detected in the women who were pregnant (+8.7-fold; p = 0.0002) as well as in the patients with hydatidiform mole (+5.6-fold; p < 0.0001) relative to the controls (Figure 3). The gene discussed is ITIH4; the disease is hydatidiform mole.