RELN and Alzheimer disease: However, despite the unknown causal link and the limitations of our sample size, a correlation analyses highlighted a significant relationship between the levels of the 60 kDa fragment and the overall CAm density in subiculum and pre/parasubiculum in ND subjects (subiculum: r=0.857, p=0.004; pre/parasubiculum: r=0.845, p=0.006) that was lost in AD patient (subiculum: r=0.098, p=0.826: pre/parasubiculum: r=0.275, p=0.529), pointing to putative alterations in Reelin proteolytic degradation in AD.