The frequent detection of CAm within axons and terminal neurites in the aging ocular system [64], as well as the prominent accumulation of axonal proteins including Tau [56,65], APP [66], and α-Synuclein [56], indicate that they may form in response to cellular stress and/or aging-related impairments in cytoskeletal stability and axonal transport that ultimately lead to axonal swellings, a mechanism recently proposed for amyloid plaque formation in AD [9]. Here, APP is linked to Alzheimer disease.