KRT18 and metabolic dysfunction-associated steatohepatitis: Levels of CK18 fragments ≥225 U/L, ≥ 250 U/L, or ≥ 300 U/L had sensitivity of 70%, 60%, or 53%; specificity of 82%, 93%, or 100%; PPV of 84%, 95%, or 100%; and negative predictive value (NPV) of 73%, 69%, or 67% for the diagnosis of NASH, respectively [43].