Studies of Kuhn et al. revealed evidence that increased IGF-1 signaling through enhanced IGF-1 secretion and IGF-1R activation was associated with the phenotype of resistance in bortezomib-resistant cell lines selected from RPMI 8226, OPM-2, ANBL-6, and KAS-6/1 myeloma cell lines by bortezomib exposure and no PSMB5 mutations were found in these bortezomib-resistant cell lines. The gene discussed is IGF1R; the disease is plasma cell myeloma.