NFKB1 and neoplasm: Bortezomib, inhibiting the chymotrypsin-like activity at the PSMB5, blocked the degradation of the poly-ubiquitinated proteins such as IkB-.alpha;, a negative regulator of the nuclear factor (NF)-κB pathway, and unfolded or oxidatively modified proteins followed by endoplasmic reticulum (ER) stress and effects on the tumor microenvironment associated apoptosis [4].