These findings are supported by our data that EE: (1) modulated mTBI-induced upregulation of the pro-inflammatory cytokines IL-1β and TNF-α and enhanced levels of the anti-inflammatory cytokine IL-10; (2) mitigated mTBI-induced cognitive impairment; and (3) attenuated mTBI-induced downregulation in pAMPK/AMPK ratio and uMtCK levels. This evidence concerns the gene TNF and Cognitive impairment.