Mao et al. [46] compared serum GP73 and AFP in 4217 participants, including 1690 healthy adults, 337 HBV carriers, 512 patients with cirrhosis, 789 patients with HCC, 61 patients with other malignant liver lesions, 206 patients with benign liver lesions and 622 patients with 14 non-liver cancers. This evidence concerns the gene GOLM1 and hepatocellular carcinoma.