FGF7 and graft versus host disease: 44 demonstrated in a murine model where GVHD is induced by both minor and major histocompatibility antigens that KGF administration from day −3 to +7 significantly reduced GVHD mortality and the severity of GI GVHD. Correlative studies demonstrated decreased serum lipopolysaccharide and tumour necrosis factor α levels. One possible mechanism for a decrease in GVHD in murine transplantation following KGF administration is that KGF may prevent or attenuate glutathione depletion and, thus, inhibit organ damage mediated by reactive oxygen species 47.