Although no preferential target of myosin proteolysis towards MHC I or MHC II isoforms was detected in tibialis anterior and vastus lateralis samples from cancer and critical illness patients with substantial muscle atrophy and myosin loss 8,33, altered myosin expression in skeletal muscle (soleus,gastrocnemius) of tumour-bearing mice from MHC I to MHC II (slow-to-fast transition) was found 55. The gene discussed is MYH14; the disease is cancer.